As a cat owner, you want nothing but the best for your feline companion. The world of parasite prevention, however, can feel overwhelming. Walk down any pet care aisle, and you’re met with a dizzying array of collars, chews, and topical solutions, all claiming to be the best. Amid this noise, one name consistently rises to the top in veterinary clinics: Revolution Plus for cats.
But what exactly is it? How does it differ from the original Revolution? Is it safe for your cuddly kitten or your senior cat? As veterinary professionals, we are tasked with cutting through the marketing hype and providing clear, evidence-based information.
This definitive guide will delve into everything you need to know about Revolution Plus for cats, from its mechanism of action to an honest comparison with its main competitors. Our goal is to empower you to have an informed conversation with your veterinarian about the best parasite protection for your unique feline friend.
What is Revolution Plus For Cats? More Than Just Flea Prevention
At its core, Revolution Plus is a prescription-only, broad-spectrum topical parasiticide. This means it’s applied directly to your cat’s skin, typically at the base of the neck, and it protects against a wide range of internal and external parasites.
It is the evolved successor to the original Revolution (selamectin). The critical “Plus” refers to the addition of a second active ingredient: sarolaner. This powerful combination transforms it from a great product into a comprehensive shield, specifically adding robust tick protection to an already impressive portfolio.
It’s crucial to understand that Revolution Plus is a prescription medication. This isn’t an arbitrary hurdle; it’s a vital safety measure. Your veterinarian must ensure the product is appropriate for your cat’s age, weight, and health status. This prescription status also guarantees you are receiving an authentic, properly stored product, not a potentially dangerous counterfeit. It’s widely available through veterinary clinics across the US and Canada, ensuring you get professionally dispensed medication.
What Parasites Does Revolution Plus Actually Kill?
The “Plus” in Revolution Plus for cats signifies a powerful expansion of its protective shield. It’s marketed as an “all-in-one” solution, and for good reason. Let’s break down the specific parasites it targets:
Fleas: It kills adult fleas (Ctenocephalides felis) and, critically, prevents flea eggs from hatching. This dual action is essential for breaking the flea life cycle and controlling infestations in your home.
Ticks: This is the key upgrade. It is indicated to kill the black-legged tick (also known as the deer tick, Ixodes scapularis), which can transmit Lyme disease, and the American dog tick (*Dermacentor variabilis).
Heartworm: It prevents heartworm disease caused by Dirofilaria immitis. Heartworm is transmitted by mosquitoes and is a potentially fatal disease for which treatment in cats is complex and risky. Prevention is the only true protection.
Intestinal Worms: It treats and controls roundworms (Toxocara cati) and hookworms (Ancylostoma tubaeforme), common parasites that can affect your cat’s digestive health and, in rare cases, be transmitted to humans.
Ear Mites: It effectively treats infestations of Otodectes cynotis, the most common cause of ear mites in cats, which cause intense itching and discomfort.
This wide range is precisely why a prescription for Revolution Plus can often replace multiple other products, simplifying your cat’s healthcare routine.
The Active Ingredients: How Does Revolution Plus For Cats Work?
The efficacy of Revolution Plus hinges on the synergistic partnership of its two active ingredients. They work through different mechanisms to achieve comprehensive protection.
Selamectin: This is the ingredient carried over from the original Revolution. It belongs to a class of drugs called macrocyclic lactones. It is absorbed through the skin and enters the bloodstream. When parasites like fleas, heartworm larvae, or ear mites come into contact with it, it overstimulates their nervous system, leading to paralysis and death. For intestinal worms, it interferes with their chloride channels.
Sarolaner: This is the “Plus” component. It is an isoxazoline compound that specifically targets fleas and ticks. It works by highly selectively blocking GABA and glutamate-gated chloride channels in the insect’s nervous system. This disruption leads to hyperexcitation, paralysis, and death of the parasite. It’s stored in the skin’s oil glands and hair follicles, providing sustained protection.
The powerful yet safe combination of Selamectin and Sarolaner is the engine behind the effectiveness of Revolution Plus. The topical application allows these ingredients to be distributed across the skin surface, creating a protective barrier.
Is Revolution Plus For Cats Safe? A Vet’s View on Side Effects
In our clinical experience, Revolution Plus for cats is very well-tolerated by most felines. Its safety profile has been rigorously tested, and it is approved for use in kittens as young as 8 weeks of age.
However, as with any pharmaceutical product, side effects are possible. It’s important to distinguish between common and rare reactions.
Common, Typically Mild Side Effects:
These are usually transient and resolve without intervention.
- Temporary hair loss or slight redness at the application site.
- A brief period of digestive upset (vomiting or diarrhea).
- Lethargy or increased salivation, especially if the cat manages to lick the wet application site.
Rare, More Serious Side Effects:
While uncommon, it’s crucial to be aware and contact your veterinarian immediately if you observe:
- Neurological signs such as muscle tremors, ataxia (wobbly gait), or seizures. The isoxazoline class (sarolaner) has been associated with these reactions in rare cases, particularly in cats with a history of seizures.
- Severe skin reactions like persistent itching, hives, or ulcers.
- Loss of appetite or pronounced lethargy lasting more than a day.
Pre-Application Safety Checklist:
- Weight: Always use the correct dosage size (pink for 5.5-11 lbs, orange for 11-22 lbs). Never use a dog product on a cat.
- Health Status: Inform your vet if your cat is pregnant, nursing, elderly, or has a known history of neurological disorders or illness.
- Multi-Cat Households: Revolution Plus is generally safe in households with multiple cats. To prevent mutual grooming immediately after application, consider separating the cats for a few hours until the solution dries.
As with any medication, monitor your cat after the first dose of Revolution Plus. The vast majority of cats use this product without any issues, but an informed owner is a cat’s best advocate.
How to Use Revolution Plus For Cats: A Step-by-Step Guide
To ensure the medication works correctly, proper application of Revolution Plus is key. Follow these steps for optimal efficacy:
Confirm the Prescription: Ensure you have the correct tube for your cat’s weight. Using an under-dosed product is ineffective; using an over-dosed product is dangerous.
Prepare the Site: Have the tube ready and remove it from the packaging. Position your cat comfortably. Part the fur at the base of the skull, right between the shoulder blades, until you can see the skin clearly. Applying it here prevents your cat from licking it off.
Apply the Solution: Place the tip of the tube directly against the exposed skin. Squeeze the tube firmly to empty the entire contents in one spot.
Do Not Disturb: Avoid touching the application site until it is dry. Do not bathe your cat or let them swim for at least two hours before or after application.
Maintain the Schedule: For continuous protection, Revolution Plus for cats must be applied once a month, every month. Mark your calendar or set a reminder. Consistency is critical, especially for heartworm prevention.
Always follow your veterinarian’s specific instructions when applying Revolution Plus.
Revolution Plus For Cats vs. The Competition: An Honest Comparison
How does Revolution Plus fit into the broader market of feline parasite control? Let’s compare it to other leading products to see where it shines and where alternatives might have an edge.
| Feature | Revolution Plus | Bravecto Plus | Frontline Plus | Credelio + Interceptor Combo |
| Flea/Tick Duration | 1 Month | 2 Months (Fleas/Ticks) | 1 Month | 1 Month (Credelio) |
| Heartworm & Intestinal Worms | Yes (All-in-One) | Yes (All-in-One) | No | Yes (via Interceptor) |
| Ear Mites | Yes | Yes | No | No |
| Application | Topical | Topical | Topical | Oral (Chewable) |
| Prescription Required | Yes | Yes | No | Yes |
vs. Bravecto Plus for Cats:
This is its most direct competitor. Bravecto Plus also offers all-in-one protection (fleas, ticks, heartworm, intestinal worms) but with a key difference: its flea and tick protection lasts for 2 months, while its heartworm protection is monthly. Revolution Plus requires a monthly application for all parasites. The choice often comes down to owner preference: the convenience of 2-month flea/tick control (Bravecto) versus the simplicity of a single, consistent monthly routine for everything (Revolution Plus).
vs. Frontline Plus for Cats:
Frontline Plus is a trusted, over-the-counter option. It is effective against fleas and ticks but has a critical limitation: it does not protect against heartworms or intestinal parasites. This makes Revolution Plus a significantly more comprehensive product. If you use Frontline, your cat would need a separate heartworm preventive.
vs. a Credelio & Interceptor Combo:
This involves giving two separate oral medications: Credelio (a monthly chewable for fleas/ticks) and Interceptor (a monthly chewable for heartworm and intestinal worms). This combo matches the parasite spectrum of Revolution Plus for cats. The decision here is about application: pills vs. topical. For cats that are difficult to pill, the topical solution of Revolution Plus is a clear winner.
This all-in-one nature is a primary advantage of Revolution Plus for cats, simplifying your life and ensuring no part of your cat’s parasite protection is forgotten.
Top-Rated Feline Parasite Control on Amazon (Vet-Reviewed)
While we strongly advocate for consulting your veterinarian for a prescription, we understand that owners use online platforms like Amazon for research and purchasing. Here is a vet-reviewed look at top-rated products, with crucial context to guide your decision.
Important: Always confirm with your veterinarian that any product, especially those purchased online, is authentic and appropriate for your cat’s specific health profile and local parasite risks. Ensure you have a valid prescription for prescription-only products.
Revolution Plus for Cats (Topical)
- This is the product featured in this article. It requires a prescription, which you can often get through online vet services linked on Amazon or by uploading your vet’s prescription.
- Why it’s Top-Rated: Its high rating stems from its proven, broad-spectrum efficacy and the convenience of a single monthly application. Owners appreciate the peace of mind that comes with all-in-one protection.
- Shop on Amazon
Bravecto Plus for Cats (Topical)
- A direct competitor to Revolution Plus, also prescription-only.
- Why it’s Top-Rated: The 2-month duration for fleas and ticks is a massive draw for many owners, reducing the frequency of application. Its efficacy is on par with Revolution Plus, making it a fantastic alternative.
- Shop on Amazon
Frontline Plus for Cats (Topical – OTC)
- A readily available over-the-counter option.
- Why it’s Top-Rated: Its accessibility and long-standing reputation make it a go-to for many. It’s effective for fleas and ticks.
- Crucial Vet Note: It is a good choice only if your cat is on a separate, veterinarian-recommended heartworm preventive. It does NOT provide complete protection on its own.
- Shop on Amazon
FAQs About Revolution Plus For Cats
Let’s tackle the most-searched questions about Revolution Plus for cats.
Is Revolution Plus for cats waterproof?
Yes, once it has been absorbed (after about 2 hours), bathing or swimming should not reduce the efficacy of Revolution Plus for cats. The medication is stored in the skin’s oil glands.
Can I use Revolution Plus for cats on my dog?
Absolutely not. Formulations are species-specific. The dosage and concentration of active ingredients in Revolution Plus for cats are calculated for feline physiology and metabolism. Using it on a dog can be dangerous and ineffective. Always use the product prescribed for the specific animal.
How long does it take for Revolution Plus for cats to work on fleas?
It starts killing fleas within 12 hours of application. For a full-scale infestation, it may take a couple of months to break the entire life cycle in your home environment.
What is the dosage for Revolution Plus for cats?
It is based strictly on weight, not age. Your veterinarian will prescribe the correct tube:
- Pink Tube: For cats weighing 2.8 kg (5.5 lb) up to 5.5 kg (11 lb).
- Orange Tube: For cats weighing 5.5 kg (11 lb) up to 11 kg (22 lb).
Are there any alternatives to Revolution Plus for cats?
Yes. As discussed, options like Bravecto Plus (topical, 2-month flea/tick), or a combination of a product like Seresto collar (for fleas/ticks only) with an oral heartworm preventive like Heartgard are alternatives your veterinarian can discuss based on your cat’s lifestyle and your preferences.
Can indoor cats benefit from Revolution Plus for cats?
Yes, emphatically. The “indoor-only” status is not a forcefield. Parasites can be brought in on your clothing, through open windows, or by other pets. Mosquitoes, which transmit heartworm, readily enter homes. One study found that over 25% of cats diagnosed with heartworm were considered indoor-only by their owners. Prevention is always safer and more cost-effective than treatment.
Conclusion: The Final Verdict
For a large number of feline patients, Revolution Plus for cats represents a safe, convenient, and highly effective solution for comprehensive parasite control. Its broad-spectrum coverage simplifies a complex area of pet care, and its strong safety profile makes it a trustworthy choice for kittens and adults alike.
The final decision, however, should always be made in partnership with your veterinarian. They understand your local parasite pressures (is Lyme disease prevalent? Are hookworms a major concern?) and your cat’s unique health needs.
Schedule an appointment to ask if Revolution Plus for cats is the right guardian for your feline friend. Bring your questions about cost, alternatives, and any concerns about side effects. An informed, proactive approach is the cornerstone of a long, healthy, and happy life for your cat.
Sources:
- Revolution Plus. Zoetis Inc.
- American Heartworm Society. “Heartworm in Cats.”
- Blagburn, B. L., et al. “Efficacy of a novel topical combination of selamectin and sarolaner for the treatment and control of flea infestations and prevention of heartworm disease in cats.” Parasites & Vectors vol. 10,1 602. 12 Dec. 2017, doi:10.1186/s13071-017-2555-0
- U.S. Food and Drug Administration. “Animal Drug Safety: Isoxazoline Products.”
- Companion Animal Parasite Council (CAPC). “Parasite Guidelines – Cats.”
