When it comes to keeping our feline friends healthy, protecting them from parasites is a top priority. NexGard Combo for Cats has emerged as a leading solution, offering broad-spectrum protection against fleas, ticks, heartworms, and intestinal worms. As an Amazon affiliate, I’ve thoroughly researched this product, diving into its features, customer feedback, and performance to bring you a detailed review. This guide will cover everything you need to know about NexGard Combo for Cats, including top Amazon products, pros and cons, frequently asked questions, and a comparison with other popular parasite treatments. Whether you’re a seasoned cat parent or a new pet owner, this review will help you make an informed decision to keep your cat safe and healthy.
What is the NexGard Combo for Cats?
NexGard Combo for Cats is a monthly topical solution designed to protect cats from a wide range of parasites. Manufactured by Boehringer Ingelheim, the makers of vet-recommended NexGard and HEARTGARD Plus, this product combines three active ingredients: esafoxolaner, eprinomectin, and praziquantel. These ingredients work together to kill fleas and ticks, prevent heartworm disease, and treat and control hookworms, roundworms, tapeworms, lungworms, and ear mites. It’s the first and only broad-spectrum feline parasiticide that targets tapeworms, making it a unique option for comprehensive parasite protection.
This topical treatment is applied directly to the skin, typically on the back of the neck, where cats cannot lick it off. It’s safe for cats and kittens as young as 8 weeks old and weighing at least 1.8 pounds. NexGard Combo is available in two formulations: one for small cats (1.8–5.5 lbs) and another for larger cats (5.6–16.5 lbs). For cats over 16.5 lbs, a combination of applicators may be used under veterinary guidance.
Why Choose NexGard Combo for Cats?
Parasites pose a significant threat to cats, even those that live indoors. Fleas can hitch a ride on other pets or clothing, ticks can latch on during outdoor adventures, and worms can be transmitted through contaminated environments or prey. NexGard Combo for Cats offers a convenient, one-and-done monthly solution that addresses both external and internal parasites. Its easy-to-use applicator and broad-spectrum coverage make it a favorite among cat owners looking for reliable protection.
As an Amazon affiliate, I’ve scoured the platform to find the best NexGard Combo products available. Below, I’ll highlight top picks, share a detailed review, and compare this treatment with other options to help you decide if it’s the right choice for your feline companion.
Top NexGard Combo for Cats Products on Amazon
Here are some of the top NexGard Combo for Cats products available on Amazon, based on availability, customer reviews, and pricing (as of July 21, 2025). Note that NexGard Combo requires a veterinary prescription, so you’ll need to provide pet and clinic information at checkout. Prices may vary, and availability can be limited, so act quickly to secure your order.
- NexGard Combo for Cats 5.5–16.5 lbs (3-Dose Pack)
- Price: Check Amazon for current pricing.
- Key Features: This pack includes three applicators for monthly use, designed for cats weighing 5.6–16.5 lbs. It offers protection against fleas, ticks, heartworms, and intestinal worms, including tapeworms.
- Customer Rating: 4.2 out of 5 stars (799 reviews)
- Availability: Limited stock; typically delivered in 3–6 days after prescription approval.
- Link: Check on Amazon
- NexGard Combo for Cats 1.8–5.5 lbs (3-Dose Pack)
- Price: Check Amazon for current pricing.
- Key Features: Tailored for smaller cats and kittens, this pack provides three months of protection. It’s ideal for young or petite cats and includes the same broad-spectrum coverage as the larger dose.
- Customer Rating: 4.3 out of 5 stars (based on related product reviews)
- Availability: Only 10 left in stock—order soon.
- Link: Check on Amazon
- NexGard Combo for Cats 5.5–16.5 lbs (6-Dose Pack)
- Price: Check Amazon for current pricing (varies due to prescription requirements).
- Key Features: A six-month supply for larger cats, offering cost savings for long-term use. This pack is perfect for pet owners who want to stock up on their cat’s parasite protection.
- Customer Rating: Not explicitly listed but aligns with high ratings for NexGard Combo products.
- Availability: Limited stock; requires prescription approval.
- Link: Check on Amazon
Note: Prices and availability are subject to change. Always verify prescription requirements and consult your veterinarian before purchasing.
Detailed Review of NexGard Combo for Cats
How It Works
NexGard Combo for Cats is applied topically once a month. The active ingredients—esafoxolaner, eprinomectin, and praziquantel—target different parasites:
- Esafoxolaner: Kills external parasites like fleas and ticks, including black-legged ticks and lone star ticks. It eliminates fleas within 24 hours before they can lay eggs and controls ticks like Ixodes ricinus for up to five weeks.
- Eprinomectin: Prevents heartworm disease and treats internal parasites like hookworms and roundworms.
- Praziquantel: Targets tapeworms, making NexGard Combo the only topical treatment that addresses this parasite.
The application process is straightforward: part the hair on the midline of the neck, between the base of the skull and shoulder blades, and apply the entire contents of the applicator to dry skin. Wash your hands thoroughly after use, and avoid touching the application site for at least four hours or until it’s visibly dry.
Pros of NexGard Combo for Cats
- Broad-Spectrum Protection: NexGard Combo is the only topical solution that protects against fleas, ticks, heartworms, roundworms, hookworms, tapeworms, lungworms, and ear mites. This comprehensive coverage reduces the need for multiple treatments.
- Easy Application: The topical applicator is user-friendly, making it easier to administer than oral medications, especially for cats that resist pills.
- Fast-Acting: Kills fleas within 24 hours and ticks within 48 hours, providing quick relief from infestations.
- Safe for Kittens: Approved for cats and kittens as young as 8 weeks and weighing 1.8 lbs or more, it’s suitable for young or small cats.
- Monthly Convenience: One application provides 30 days of protection, simplifying your pet care routine.
- Vet-Recommended: Backed by Boehringer Ingelheim, a trusted name in pet healthcare, and supported by rigorous safety studies.
Cons of NexGard Combo for Cats
- Potential Side Effects: Some cats may experience vomiting, lethargy, anorexia, or application site reactions. A notable concern is its use in senior cats, with one user reporting severe side effects in a 14-year-old cat, including vomiting and lethargy.
- Prescription Required: NexGard Combo is a prescription-only product, which may add an extra step for purchasing.
- Limited Effectiveness Reports: Some users have reported persistent fleas or ticks after application, though this may be due to environmental factors or the flea life cycle requiring multiple treatments.
- Cost: While effective, NexGard Combo can be expensive, with prices ranging from $22–$24 per dose. Subscribe & Save options on Amazon can help reduce costs.
- Risk of Allergic Reactions: Esafoxolaner belongs to the isoxazoline class, which may cause neurologic reactions like tremors or seizures in rare cases, particularly in cats with a history of seizures.
- Not Tested in Breeding Males: Safety has not been established for breeding male cats, so consult your vet if this applies.
Customer Feedback
Customer reviews on Amazon and other platforms like BestVetCare.com highlight NexGard Combo’s effectiveness and convenience. Many users praise its ability to tackle multiple parasites with a single application. For example, one reviewer noted, “Best combo for my beloved companion,” appreciating its comprehensive protection. Another user highlighted the “quick delivery and great discounts” when purchasing from trusted retailers.
However, some negative feedback exists. A Reddit user reported that after two days of applying NexGard Combo, their cat still had fleas and ticks, though improvement was noted after the second application. Another user shared a tragic experience, claiming their kitten’s death was linked to NexGard Combo, though this was attributed to a rare 4% incompatibility. These cases emphasize the importance of consulting a veterinarian to ensure the product is suitable for your cat.
Comparison: NexGard Combo vs. Other Flea and Tick Treatments
To help you decide if NexGard Combo for Cats is the best choice, let’s compare it with two other popular parasite treatments available on Amazon: Revolution Plus and Advantage Multi.
| Feature | NexGard Combo | Revolution Plus | Advantage Multi |
| Active Ingredients | Esafoxolaner, Eprinomectin, Praziquantel | Selamectin, Sarolaner | Imidacloprid, Moxidectin |
| Parasite Coverage | Fleas, ticks, heartworms, roundworms, hookworms, tapeworms, lungworms, ear mites | Fleas, ticks, heartworms, roundworms, hookworms, ear mites | Fleas, heartworms, roundworms, hookworms, ear mites |
| Tapeworm Protection | Yes | No | No |
| Application | Topical (monthly) | Topical (monthly) | Topical (monthly) |
| Prescription Required | Yes | Yes | Yes +++ |
| Price (3-Dose Pack) | ~$23.99 | ~$25–$30 | ~$20–$25 |
| Minimum Age/Weight | 8 weeks, 1.8 lbs | 8 weeks, 2.8 lbs | 9 weeks, 2 lbs |
| Customer Rating (Amazon) | 4.2/5 (799 reviews) | 4.5/5 (1,200+ reviews) | 4.3/5 (600+ reviews) |
| Key Advantage | Only topical that kills tapeworms | Highly effective against ticks | Budget-friendly option |
| Key Disadvantage | Potential side effects in senior cats | No tapeworm protection | No tick protection |
NexGard Combo vs. Revolution Plus
Revolution Plus is a strong competitor, offering protection against fleas, ticks, heartworms, roundworms, hookworms, and ear mites. However, it lacks tapeworm coverage, which is a significant advantage for NexGard Combo. Some users report that Revolution Plus is more effective at preventing ticks, particularly in areas with high tick populations. On Reddit, a user noted that after switching to NexGard Combo, their cat still had ticks, prompting them to return to Revolution Plus. However, NexGard Combo’s tapeworm protection makes it a better choice for cats at risk of internal parasites.
NexGard Combo vs. Advantage Multi
Advantage Multi is a more budget-friendly option but doesn’t protect against ticks, making it less comprehensive than NexGard Combo. It’s a good choice for indoor cats with minimal tick exposure but falls short for outdoor cats or those in tick-heavy regions. NexGard Combo’s broader coverage, including tapeworms, makes it a more versatile option for multi-parasite protection.
FAQs About NexGard Combo for Cats
Most common questions from pet owners, here are answers to frequently asked questions about NexGard Combo for Cats:
How long does it take for NexGard Combo to work?
NexGard Combo kills fleas within 24 hours and ticks within 48 hours. For heartworm prevention and intestinal worm control, it provides protection for 30 days when applied monthly. Consistent use is key to breaking the flea life cycle, which may take 3–6 months in heavily infested environments.
Is NexGard Combo safe for senior cats?
While generally safe for cats 8 weeks and older, some senior cats may experience side effects like vomiting, lethargy, or anorexia. One user reported severe reactions in a 14-year-old cat, so consult your vet before using it on older or health-compromised cats.
Can I use NexGard Combo with other medications?
No documented drug interactions exist, but always inform your veterinarian about other medications your cat is taking to avoid potential issues.
What if my cat gets wet after application?
The product should be applied to dry skin, and you should avoid bathing or exposing your cat to water for at least a few hours until the solution is dry. The effectiveness after water immersion has not been fully evaluated.
Does NexGard Combo require a prescription?
Yes, NexGard Combo is a prescription-only product. You’ll need to provide veterinary approval when purchasing from Amazon or other retailers.
Can I split a dose between two cats?
No, you should not split doses. Each applicator is formulated for a specific weight range, and splitting doses may result in under- or overdosing. Consult your vet for appropriate dosing based on your cats’ weights.
What should I do if my cat experiences side effects?
If your cat shows signs of an allergic reaction (e.g., swelling, difficulty breathing, or excessive salivation) or other side effects like vomiting or lethargy, contact your veterinarian immediately or visit an emergency clinic.
Tips for Using NexGard Combo for Cats
To maximize the effectiveness of NexGard Combo and ensure your cat’s safety, follow these tips:
- Apply Correctly: Part the fur and apply the entire dose to dry skin in an area your cat can’t lick, such as the back of the neck.
- Use Year-Round: Parasites can be a threat even in colder months, so apply NexGard Combo monthly for continuous protection.
- Treat the Environment: To fully eliminate fleas, treat your home and bedding with appropriate products, as the flea life cycle can persist in carpets and furniture.
- Monitor for Side Effects: Watch your cat for signs of adverse reactions, especially during the first few applications.
- Consult Your Vet: Ensure your cat is tested for heartworm before starting treatment, and discuss any health concerns, especially for senior or breeding cats.
Why Buy NexGard Combo for Cats on Amazon?
As an Amazon affiliate, I recommend purchasing NexGard Combo for Cats through Amazon for several reasons:
- Competitive Pricing: Amazon offers prices like $21.59 for a 3-dose pack with Subscribe & Save, making it cost-effective for long-term use.
- Fast Shipping: Eligible for free shipping on orders over $35, with delivery typically in 3–6 days after prescription approval.
- Customer Reviews: Access to thousands of reviews helps you gauge real-world performance and user experiences.
- Convenience: Amazon’s easy checkout process and prescription verification streamline the purchasing experience.
Conclusion
NexGard Combo for Cats is a game-changer in feline parasite protection, offering unmatched coverage against fleas, ticks, heartworms, and intestinal worms, including tapeworms. Its easy-to-use topical applicator, fast-acting formula, and vet-recommended status make it a top choice for cat owners. While it comes with a higher price tag and potential side effects in some cats, its comprehensive protection and convenience outweigh these drawbacks for most users.
By purchasing NexGard Combo for Cats on Amazon, you can take advantage of competitive pricing, fast shipping, and user reviews to make an informed decision. Whether you choose the 3-dose or 6-dose pack, this product is a reliable way to keep your cat healthy and parasite-free. Always consult your veterinarian to ensure NexGard Combo is suitable for your cat, especially if they have specific health conditions or are senior pets.
For the best deals, check out the Amazon links above and consider the Subscribe & Save option for additional savings. Protect your feline friend with NexGard Combo for Cats today, and give them the year-round care they deserve!
Disclaimer: This blog post contains affiliate links, and as an Amazon Associate, I earn from qualifying purchases. This means I may receive a small commission at no additional cost to you if you purchase products through the links provided. All opinions and recommendations in this review are my own and product descriptions, customer feedback, and analysis of available information. Always check the latest reviews and product details before purchasing. Prices and product availability are subject to change, so please verify details on Amazon before purchasing. Always consult your veterinarian before making dietary changes for your cat. Thank you for supporting this blog!
Sources
- PetSmart: NexGard COMBO Topical Solution for Cats
- BestVetCare: NexGard Combo for Cats Reviews
- Petco: NexGard COMBO Topical for Cats
- Pet VM: NexGard COMBO Topical for Cats and Kittens
- Canada Pet Care: Buy NexGard Combo for Cats
- Amazon: NexGard Combo for Cats Product Listings
- Reddit: Revolution vs. NexGard Combo for Cats Discussion
- NexGard for Pets: Official Product Information
- VetRxDirect: NexGard Combo for Cats
- PetCounter: NexGard Combo for Large Cats
